In: JCI Insight
Blood pressure has a circadian rhythm, dipping during the night and elevated during the day. In some individuals this nocturnal dip is absent. This is called non-dipping and is associated with adverse cardiovascular and renal outcomes. My research aims to determine the mechanisms of blood pressure rhythmicity and how these are altered in disease. I use mouse models to investigate the contribution of renal tubular sodium handling as well as vascular resistance to the circadian rhythm of blood pressure.