The primary focus of my research is high frequency ultrasound and ultrasonic contrast agents. In 2008, with Wellcome Trust funding (£516K), I established the preclinical ultrasound imaging facility at the University of Edinburgh, expanding this in 2019 to incorporate a Vevo 3100 ultrasound scanner. I have also been a co-applicant on a successful application to the Wellcome Trust to establish a preclinical large animal imaging facility (2014). Using ultrasound imaging, we can image adult, neonates and embryonic hearts, livers and kidneys of small and large animals and study their structure and blood flow dynamics in real-time. Using in-house and commerically available ultrasonic contrast agents we can study the perfusion of organs over time. My research focusses on developing mechanisms to target these microbubbles to biological markers expressed on the surface of tissues and to develop novel methods to image these microbubbles.